/* SequenceMedicine Network — Unified Base Stylesheet
   Version: 2.0 | 2026-03-07
   Aligned with sequencemedicine.com design language
   ────────────────────────────────────────────────── */

/* ── Reset ─────────────────────────────────────── */
*, *::before, *::after {
  box-sizing: border-box;
  margin: 0;
  padding: 0;
}

/* ── Design Tokens ─────────────────────────────── */
:root {
  /* Brand palette — matches sequencemedicine.com */
  --blue-700: #1d4ed8;
  --blue-600: #2563eb;
  --blue-500: #3b82f6;
  --blue-400: #60a5fa;
  --blue-100: #dbeafe;
  --blue-50:  #eff6ff;

  /* Neutrals */
  --gray-900: #111827;
  --gray-800: #1f2937;
  --gray-700: #374151;
  --gray-600: #4b5563;
  --gray-500: #6b7280;
  --gray-400: #9ca3af;
  --gray-300: #d1d5db;
  --gray-200: #e5e7eb;
  --gray-100: #f3f4f6;
  --gray-50:  #f9fafb;
  --white:    #ffffff;

  /* Status */
  --green-600: #16a34a;
  --green-100: #dcfce7;
  --amber-600: #d97706;
  --amber-100: #fef3c7;

  /* Site-level accent (override per site) */
  --accent: #2563eb;
  --accent-light: #dbeafe;

  /* Legacy compat */
  --bg: #ffffff;
  --bg-alt: #f9fafb;
  --text: #1f2937;
  --text-muted: #6b7280;
  --border: #e5e7eb;

  /* Typography */
  --font-sans: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
  --font-heading: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
  --font-body: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
  --font-mono: 'JetBrains Mono', 'SF Mono', monospace;

  /* Layout */
  --max-width: 960px;
  --nav-height: 56px;
  --bar-height: 36px;
  --radius: 8px;

  /* Shadows */
  --shadow-sm: 0 1px 2px rgba(0,0,0,0.05);
  --shadow-md: 0 4px 6px -1px rgba(0,0,0,0.07), 0 2px 4px -2px rgba(0,0,0,0.05);

  /* Transitions */
  --transition-fast: 150ms ease;
  --transition-base: 250ms ease;
}

/* ── Global ────────────────────────────────────── */
html {
  font-size: 16px;
  scroll-behavior: smooth;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

body {
  font-family: var(--font-body);
  background: var(--white);
  color: var(--gray-800);
  line-height: 1.65;
  padding-top: calc(var(--bar-height) + var(--nav-height));
}

img { max-width: 100%; display: block; height: auto; }
a { color: var(--accent); text-decoration: none; transition: color var(--transition-fast); }
a:hover { color: var(--blue-700); }
strong { font-weight: 600; }

/* ── Typography ────────────────────────────────── */
h1, h2, h3, h4 {
  font-family: var(--font-heading);
  color: var(--gray-900);
  line-height: 1.25;
  font-weight: 700;
}

h1 { font-size: clamp(1.75rem, 4vw, 2.25rem); margin-bottom: 0.5em; letter-spacing: -0.02em; }
h2 { font-size: 1.5rem; margin: 2em 0 0.6em; letter-spacing: -0.01em; }
h3 { font-size: 1.15rem; margin: 1.5em 0 0.4em; }
h4 { font-size: 1rem; margin: 1em 0 0.3em; }
p { margin-bottom: 1.1em; color: var(--gray-700); }

blockquote {
  border-left: 3px solid var(--accent);
  padding: 0.8em 1.2em;
  margin: 1.5em 0;
  background: var(--blue-50);
  border-radius: 0 var(--radius) var(--radius) 0;
  font-style: italic;
  color: var(--gray-600);
}

/* ── Unified Network Bar ──────────────────────── */
#sm-unified-bar {
  position: fixed;
  top: 0; left: 0; right: 0;
  z-index: 9990;
  height: var(--bar-height);
  background: #0f172a;
  border-bottom: 1px solid rgba(59,130,246,0.15);
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 0 1rem;
  font-family: var(--font-sans);
}

#sm-unified-bar a {
  color: #94a3b8;
  text-decoration: none;
  font-size: 0.7rem;
  font-weight: 500;
  transition: color 0.2s;
  display: flex;
  align-items: center;
  gap: 0.3rem;
}

#sm-unified-bar a:hover { color: #e2e8f0; }
#sm-unified-bar .sm-bar-brand { color: #64748b; font-size: 0.7rem; letter-spacing: 0.01em; }
#sm-unified-bar .sm-bar-brand strong { color: #3b82f6; }
#sm-unified-bar .sm-bar-links { display: flex; gap: 0.75rem; }
#sm-unified-bar .sm-bar-links a.active { color: #3b82f6; }

@media (max-width: 640px) {
  #sm-unified-bar .sm-bar-links { gap: 0.4rem; }
  #sm-unified-bar .sm-bar-links a { font-size: 0.6rem; }
}

/* ── Site Header ───────────────────────────────── */
header, .site-header {
  position: fixed;
  top: var(--bar-height);
  left: 0; right: 0;
  z-index: 9980;
  height: var(--nav-height);
  background: rgba(255,255,255,0.97);
  backdrop-filter: blur(12px);
  -webkit-backdrop-filter: blur(12px);
  border-bottom: 1px solid var(--gray-200);
  padding: 0;
}

header .container, .site-header .container {
  display: flex;
  justify-content: space-between;
  align-items: center;
  height: 100%;
  max-width: var(--max-width);
  margin: 0 auto;
  padding: 0 1.5rem;
}

.site-name {
  font-family: var(--font-heading);
  font-size: 1.05rem;
  font-weight: 700;
  color: var(--gray-900);
  letter-spacing: -0.02em;
}

nav a, .site-nav a {
  margin-left: 1.5rem;
  font-size: 0.85rem;
  color: var(--gray-500);
  font-weight: 500;
  text-decoration: none;
}

nav a:hover, .site-nav a:hover { color: var(--accent); text-decoration: none; }

/* ── Layout ────────────────────────────────────── */
.container { max-width: var(--max-width); margin: 0 auto; padding: 0 1.5rem; }

.hero {
  padding: 3.5rem 1.5rem 2.5rem;
  text-align: center;
  background: linear-gradient(135deg, var(--blue-50) 0%, var(--white) 50%, var(--gray-50) 100%);
  border-bottom: 1px solid var(--gray-100);
}

.hero .subtitle {
  font-size: 1.05rem;
  color: var(--gray-500);
  max-width: 600px;
  margin: 0 auto;
  line-height: 1.6;
  font-weight: 400;
}

.content { padding: 2rem 1.5rem 3rem; max-width: var(--max-width); margin: 0 auto; }
.content img { max-width: 100%; height: auto; border-radius: var(--radius); }

/* ── Card Grid ─────────────────────────────────── */
.card-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(260px, 1fr));
  gap: 1.25rem;
  margin: 1.5rem 0;
}

.card {
  background: var(--white);
  border: 1px solid var(--gray-200);
  border-radius: var(--radius);
  padding: 1.25rem;
  transition: box-shadow var(--transition-base), border-color var(--transition-base);
}

.card:hover {
  box-shadow: var(--shadow-md);
  border-color: var(--gray-300);
}

.card h3 { margin-top: 0; font-size: 0.95rem; color: var(--gray-900); }
.card p { font-size: 0.875rem; color: var(--gray-600); margin-bottom: 0; line-height: 1.55; }

/* ── Info Box ──────────────────────────────────── */
.info-box {
  background: var(--blue-50);
  border-left: 3px solid var(--accent);
  padding: 1.25rem 1.5rem;
  border-radius: 0 var(--radius) var(--radius) 0;
  margin: 1.5rem 0;
  font-size: 0.9rem;
}

.info-box h3 { color: var(--blue-700); font-size: 0.9rem; margin-top: 0; }

.info-box ul {
  list-style: none;
  padding: 0;
  columns: 2;
  column-gap: 1.5rem;
}

.info-box li {
  font-size: 0.82rem;
  color: var(--gray-600);
  padding: 0.2rem 0;
  border-bottom: 1px solid rgba(37,99,235,0.06);
}

.info-box li::before {
  content: "›";
  color: var(--accent);
  margin-right: 0.5rem;
  font-weight: 600;
}

/* ── Tags ──────────────────────────────────────── */
.tag {
  display: inline-block;
  background: var(--accent-light);
  color: var(--accent);
  font-size: 0.72rem;
  font-weight: 600;
  padding: 0.15em 0.6em;
  border-radius: 9999px;
  margin: 0.15em;
  letter-spacing: 0.02em;
}

/* ── Table of Contents ─────────────────────────── */
.toc {
  background: var(--gray-50);
  border: 1px solid var(--gray-200);
  border-radius: var(--radius);
  padding: 1.2rem 1.5rem;
  margin: 1.5rem 0 2rem;
}

.toc h3, .toc h4 { font-size: 0.8rem; text-transform: uppercase; letter-spacing: 0.05em; color: var(--gray-500); margin-bottom: 0.6em; }
.toc ul { list-style: none; padding: 0; }
.toc li { padding: 0.25em 0; }
.toc a { font-size: 0.875rem; color: var(--gray-700); }
.toc a:hover { color: var(--accent); }

/* ── Network Badge ─────────────────────────────── */
.network-badge {
  display: inline-flex;
  align-items: center;
  gap: 0.35rem;
  font-size: 0.72rem;
  color: var(--gray-400);
  border: 1px solid var(--gray-200);
  padding: 0.2rem 0.65rem;
  border-radius: 9999px;
}

.network-badge strong { color: var(--accent); }

/* ── Footer ────────────────────────────────────── */
footer, .site-footer {
  border-top: 1px solid var(--gray-100);
  padding: 2.5rem 1.5rem;
  text-align: center;
  font-size: 0.78rem;
  color: var(--gray-400);
  background: var(--gray-50);
}

footer a, .site-footer a { color: var(--gray-400); }
footer a:hover, .site-footer a:hover { color: var(--accent); }

.footer-brand {
  font-size: 0.72rem;
  color: var(--gray-400);
  margin-top: 0.5rem;
}

.footer-brand a { color: var(--blue-500); }

.disclaimer {
  font-size: 0.68rem;
  color: var(--gray-400);
  margin-top: 0.75rem;
  font-style: italic;
}

/* ── Responsive ────────────────────────────────── */
@media (max-width: 768px) {
  h1 { font-size: 1.6rem; }
  .hero { padding: 2.5rem 1rem 2rem; }
  nav a, .site-nav a { margin-left: 1rem; font-size: 0.8rem; }
  .card-grid { grid-template-columns: 1fr; }
  .info-box ul { columns: 1; }
}

/* ── Utilities ─────────────────────────────────── */
.text-sm { font-size: 0.875rem; }
.text-xs { font-size: 0.75rem; }
.text-center { text-align: center; }

/* ── Print ─────────────────────────────────────── */
@media print {
  #sm-unified-bar, header, .site-header, nav { display: none !important; }
  body { padding-top: 0 !important; font-size: 12pt; }
}